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Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Abstract:

To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variati...

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Publisher copy:
10.1038/ng.2383

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Journal:
Nature Genetics
Volume:
44
Issue:
9
Pages:
981-990
Publication date:
2012-09-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Source identifiers:
360223
Language:
English
Pubs id:
pubs:360223
UUID:
uuid:24800c82-0be9-4c33-9d73-77d1556490d9
Local pid:
pubs:360223
Deposit date:
2013-11-16

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