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Dopamine neuron-derived IGF-1 controls dopamine neuron firing, skill learning, and exploration.

Abstract:

Midbrain dopamine neurons, which can be regulated by neuropeptides and hormones, play a fundamental role in controlling cognitive processes, reward mechanisms, and motor functions. The hormonal actions of insulin-like growth factor 1 (IGF-1) produced by the liver have been well described, but the role of neuronally derived IGF-1 remains largely unexplored. We discovered that dopamine neurons secrete IGF-1 from the cell bodies following depolarization, and that IGF-1 controls release of dopami...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1806820116

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy & Genetics
Role:
Author
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Wellcome Trust More from this funder
Medical Research Council More from this funder
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
116
Issue:
9
Pages:
3817-3826
Publication date:
2019-02-11
Acceptance date:
2018-12-27
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pmid:
30808767
Source identifiers:
982010
Language:
English
Keywords:
Pubs id:
pubs:982010
UUID:
uuid:247ee2a5-7eb8-42ca-9a2c-2b40f06974d0
Local pid:
pubs:982010
Deposit date:
2019-08-29

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