Journal article
Dopamine neuron-derived IGF-1 controls dopamine neuron firing, skill learning, and exploration.
- Abstract:
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Midbrain dopamine neurons, which can be regulated by neuropeptides and hormones, play a fundamental role in controlling cognitive processes, reward mechanisms, and motor functions. The hormonal actions of insulin-like growth factor 1 (IGF-1) produced by the liver have been well described, but the role of neuronally derived IGF-1 remains largely unexplored. We discovered that dopamine neurons secrete IGF-1 from the cell bodies following depolarization, and that IGF-1 controls release of dopami...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.0MB)
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- Publisher copy:
- 10.1073/pnas.1806820116
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Authors
Funding
Wellcome Trust
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Medical Research Council
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Bibliographic Details
- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences Journal website
- Volume:
- 116
- Issue:
- 9
- Pages:
- 3817-3826
- Publication date:
- 2019-02-11
- Acceptance date:
- 2018-12-27
- DOI:
- EISSN:
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1091-6490
- ISSN:
-
0027-8424
- Pmid:
-
30808767
- Source identifiers:
-
982010
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:982010
- UUID:
-
uuid:247ee2a5-7eb8-42ca-9a2c-2b40f06974d0
- Local pid:
- pubs:982010
- Deposit date:
- 2019-08-29
Terms of use
- Copyright date:
- 2019
- Notes:
- This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY)
- Licence:
- CC Attribution (CC BY)
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