The inverted neurogenetic gradient of the mammalian isocortex: development and evolution.

Journal article

In this paper we review recent evidence on the molecular control of cell migration in the isocortex, and present an hypothesis for the evolutionary origin of the inside-out neurogenetic gradient of this structure. We suggest that there are at least two key factors involved in the acquisition of the inside-out gradient: (i) the expression of the protein reelin, which arrests the migration of cortical plate cells by detaching them from the radial glial fiber. This permits younger neurons to use...

Expand abstract

Authors: Aboitiz, F; Morales, D; Montiel, J

• Journal: Brain research. Brain research reviews
• Volume: 38
• Issue: 1-2
• Pages: 129-139
• Publication date: 2001-12-01
• DOI: 10.1016/s0006-8993(01)02902-x
• ISSN: 0165-0173
• Language: English
• Keywords: Animals; Neurons; Humans; Biological Evolution; Cyclin-Dependent Kinases; Cell Adhesion Molecules, Neuronal; Nerve Tissue Proteins; Cyclin-Dependent Kinase 5; Cerebral Cortex; Cell Movement; Signal Transduction; Extracellular Matrix Proteins; Neuroglia; Serine Endopeptidases