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Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice.

Abstract:

This study investigated the function of each of the hypoxia inducible factor (HIF) prolyl-4-hydroxylase enzymes (PHD1–3) in the first 24 h following transient focal cerebral ischaemia by using mice with each isoform genetically suppressed. Male, 8- to 12-week old PHD1−/−, PHD2+/− and PHD3−/− mice and their wild-type (WT) littermate were subjected to 45 min of middle cerebral artery occlusion (MCAO). During the experiments, regional cerebral blood flow (rCBF) was recorded by laser Doppler flow...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Journal:
Journal of physiology
Volume:
590
Issue:
Pt 16
Pages:
4079-4091
Publication date:
2012-08-01
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Source identifiers:
350817
Language:
English
Keywords:
Pubs id:
pubs:350817
UUID:
uuid:24748ec4-dca7-4c82-b495-1028e25d5dcd
Local pid:
pubs:350817
Deposit date:
2012-12-19

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