Journal article
Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice.
- Abstract:
-
This study investigated the function of each of the hypoxia inducible factor (HIF) prolyl-4-hydroxylase enzymes (PHD1–3) in the first 24 h following transient focal cerebral ischaemia by using mice with each isoform genetically suppressed. Male, 8- to 12-week old PHD1−/−, PHD2+/− and PHD3−/− mice and their wild-type (WT) littermate were subjected to 45 min of middle cerebral artery occlusion (MCAO). During the experiments, regional cerebral blood flow (rCBF) was recorded by laser Doppler flow...
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- Publication status:
- Published
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- Publisher copy:
- 10.1113/jphysiol.2012.232884
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Bibliographic Details
- Journal:
- Journal of physiology
- Volume:
- 590
- Issue:
- Pt 16
- Pages:
- 4079-4091
- Publication date:
- 2012-08-01
- DOI:
- EISSN:
-
1469-7793
- ISSN:
-
0022-3751
- Source identifiers:
-
350817
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:350817
- UUID:
-
uuid:24748ec4-dca7-4c82-b495-1028e25d5dcd
- Local pid:
- pubs:350817
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2012
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