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aCGH.Spline--an R package for aCGH dye bias normalization.

Abstract:

MOTIVATION: The careful normalization of array-based comparative genomic hybridization (aCGH) data is of critical importance for the accurate detection of copy number changes. The difference in labelling affinity between the two fluorophores used in aCGH-usually Cy5 and Cy3-can be observed as a bias within the intensity distributions. If left unchecked, this bias is likely to skew data interpretation during downstream analysis and lead to an increased number of false discoveries. RESULTS: In ...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Bioinformatics (Oxford, England) More from this journal
Volume:
27
Issue:
9
Pages:
1195-1200
Publication date:
2011-05-01
DOI:
EISSN:
1367-4811
ISSN:
1367-4803
Language:
English
Keywords:
Pubs id:
pubs:490709
UUID:
uuid:2473771b-a7a9-43e8-8537-f303750a84dc
Local pid:
pubs:490709
Source identifiers:
490709
Deposit date:
2014-12-04

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