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Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells.

Abstract:

OBJECTIVE: Paracrine signaling via gamma-aminobutyric acid (GABA) and GABA(A) receptors (GABA(A)Rs) has been documented in rodent islets. Here we have studied the importance of GABAergic signaling in human pancreatic islets. RESEARCH DESIGN AND METHODS: Expression of GABA(A)Rs in islet cells was investigated by quantitative PCR, immunohistochemistry, and patch-clamp experiments. Hormone release was measured from intact islets. GABA release was monitored by whole-cell patch-clamp measurements ...

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Publication status:
Published

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Publisher copy:
10.2337/db09-0797

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Journal:
Diabetes
Volume:
59
Issue:
7
Pages:
1694-1701
Publication date:
2010-07-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:246fcc80-6dc3-4805-a276-1be254117de6
Source identifiers:
53326
Local pid:
pubs:53326

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