Journal article
Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells.
- Abstract:
-
OBJECTIVE: Paracrine signaling via gamma-aminobutyric acid (GABA) and GABA(A) receptors (GABA(A)Rs) has been documented in rodent islets. Here we have studied the importance of GABAergic signaling in human pancreatic islets. RESEARCH DESIGN AND METHODS: Expression of GABA(A)Rs in islet cells was investigated by quantitative PCR, immunohistochemistry, and patch-clamp experiments. Hormone release was measured from intact islets. GABA release was monitored by whole-cell patch-clamp measurements ...
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- Publication status:
- Published
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- Publisher copy:
- 10.2337/db09-0797
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Authors
Bibliographic Details
- Journal:
- Diabetes
- Volume:
- 59
- Issue:
- 7
- Pages:
- 1694-1701
- Publication date:
- 2010-07-01
- DOI:
- EISSN:
-
1939-327X
- ISSN:
-
0012-1797
- Source identifiers:
-
53326
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:53326
- UUID:
-
uuid:246fcc80-6dc3-4805-a276-1be254117de6
- Local pid:
- pubs:53326
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2010
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