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TP53 suppression promotes erythropoiesis in del(5q) MDS, suggesting a targeted therapeutic strategy in lenalidomide-resistant patients.

Abstract:

Stabilization of p53 in erythroid precursors in response to nucleosomal stress underlies the hypoplastic anemia in myelodysplastic syndromes (MDS) with chromosome 5q deletion [del(5q)]. We investigated whether cenersen, a clinically active 20-mer antisense oligonucleotide complementary to TP53 exon10, could suppress p53 expression and restore erythropoiesis in del(5q) MDS. Cenersen treatment of ribosomal protein S-14-deficient erythroblasts significantly reduced cellular p53 and p53-up-regula...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1311055110

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
110
Issue:
40
Pages:
16127-16132
Publication date:
2013-10-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
429172

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