Journal article
Lesions induced in DNA by ultraviolet light are repaired at the nuclear cage.
- Abstract:
- In mammalian cells, S-phase DNA synthesis occurs at sites fixed to a sub-nuclear structure, the nuclear matrix or cage. This is an ordered network of non-histone proteins, which maintains its essential morphology even in the absence of DNA. We show here that unscheduled DNA synthesis following exposure of HeLa cells to ultraviolet light also takes place at this sub-structure. We also show that ultraviolet irradiation grossly reorganizes nuclear DNA, arresting S-phase synthesis at the cage and leaving the residual synthesis highly localized.
- Publication status:
- Published
Actions
Authors
Bibliographic Details
- Journal:
- Journal of cell science
- Volume:
- 70
- Issue:
- AUG
- Pages:
- 189-196
- Publication date:
- 1984-08-01
- EISSN:
-
1477-9137
- ISSN:
-
0021-9533
- Source identifiers:
-
6151
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:6151
- UUID:
-
uuid:24699fac-bb7b-4126-8e9c-514173f09a24
- Local pid:
- pubs:6151
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1984
If you are the owner of this record, you can report an update to it here: Report update to this record