Direct triggering of B lymphocytes by insolubilized antigen.
The in vitro immune response of mouse spleen cells to trinitrophenylated keyhole limpet hemocyanin (TNP KLH) conjugated onto Sepharose beads, TNP KLH(B), was investigated. Both primed and unprimed spleen cells responded well to this antigen. TNP KLH primed spleen gave a greater IgM, but a lesser IgG response to TNP KLH(B) than to soluble TNP KLH [TNP KLH(S)], regardless of its concentration. Spleen cell populations depleted of T cells or macrophages responded well to TNP KLH(B), but not to TN...Expand abstract
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