Positive and negative elements regulate a melanocyte-specific promoter.

Journal article

Melanocytes are specialized cells residing in the hair follicles, the eye, and the basal layer of the human epidermis whose primary function is the production of the pigment melanin, giving rise to skin, hair, and eye color. Melanogenesis, a process unique to melanocytes that involves the processing of tyrosine by a number of melanocyte-specific enzymes, including tyrosinase and tyrosinase-related protein 1 (TRP-1), occurs only after differentiation from the melanocyte precursor, the melanobl...

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Authors: Lowings, P; Yavuzer, U; Goding, C

• Publication status: Published
• Journal: Molecular and cellular biology
• Volume: 12
• Issue: 8
• Pages: 3653-3662
• Publication date: 1992-08-01
• EISSN: 1098-5549
• ISSN: 0270-7306
• Language: English
• Keywords: Membrane Glycoproteins; Humans; Polymerase Chain Reaction; Melanocytes; Amino Acid Sequence; Promoter Regions, Genetic; Oligodeoxyribonucleotides; Base Sequence; Simplexvirus; Introns; Mice; Oxidoreductases; Animals; Gene Expression; Restriction Mapping; Genes, Regulator; Nuclear Proteins; Genomic Library; Molecular Sequence Data; Proteins; Genes, Viral; Melanoma, Experimental