Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis.

Journal article

OBJECTIVE: We have previously identified in articular cartilage an abundant pool of the heparin-binding growth factor, fibroblast growth factor 2 (FGF-2), which is bound to the pericellular matrix heparan sulfate proteoglycan, perlecan. This pool of FGF-2 activates chondrocytes upon tissue loading and is released following mechanical injury. In vitro, FGF-2 suppresses interleukin-1-driven aggrecanase activity in human cartilage explants, suggesting a chondroprotective role in vivo. We undert...

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Authors: Chia, S; Sawaji, Y; Burleigh, A; McLean, C; Inglis, J

• Publication status: Published
• Journal: Arthritis and rheumatism
• Volume: 60
• Issue: 7
• Pages: 2019-2027
• Publication date: 2009-07-01
• DOI: 10.1002/art.24654
• EISSN: 1529-0131
• ISSN: 0004-3591
• Language: English
• Keywords: Heparan Sulfate Proteoglycans; Aggrecans; Interleukin-1; ADAM Proteins; Mice; Osteoarthritis; Mice, Knockout; Joints; Animals; Fibroblast Growth Factor 2; Tumor Necrosis Factor-alpha; Cartilage, Articular; Disease Models, Animal; RNA, Messenger