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Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells

Abstract:

Macroautophagy/autophagy inhibition is a novel anticancer therapeutic strategy, especially for tumors driven by mutant RAS. Here, we demonstrate that autophagy inhibition in RAS-mutated cells induces epithelial-mesenchymal transition (EMT), which is associated with enhanced tumor invasion. This is at least partially achieved by triggering the NFKB/NF-κB pathway via SQSTM1/p62. Knockdown of ATG3 or ATG5 increases oncogenic RAS-induced expression of ZEB1 and SNAI2/Snail2, and activates NFKB act...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1080/15548627.2019.1569912

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Publisher:
Taylor and Francis Publisher's website
Journal:
Autophagy Journal website
Volume:
15
Issue:
5
Pages:
886-899
Publication date:
2019-02-20
Acceptance date:
2018-10-28
DOI:
EISSN:
1554-8635
ISSN:
1554-8627
Pubs id:
pubs:935298
URN:
uri:244b1ff6-de0f-4537-91df-a667a5c483d0
UUID:
uuid:244b1ff6-de0f-4537-91df-a667a5c483d0
Local pid:
pubs:935298

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