Journal article
Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells
- Abstract:
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Macroautophagy/autophagy inhibition is a novel anticancer therapeutic strategy, especially for tumors driven by mutant RAS. Here, we demonstrate that autophagy inhibition in RAS-mutated cells induces epithelial-mesenchymal transition (EMT), which is associated with enhanced tumor invasion. This is at least partially achieved by triggering the NFKB/NF-κB pathway via SQSTM1/p62. Knockdown of ATG3 or ATG5 increases oncogenic RAS-induced expression of ZEB1 and SNAI2/Snail2, and activates NFKB act...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
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- Files:
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(pdf, 4.6MB)
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- Publisher copy:
- 10.1080/15548627.2019.1569912
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Authors
Funding
Bibliographic Details
- Publisher:
- Taylor and Francis Publisher's website
- Journal:
- Autophagy Journal website
- Volume:
- 15
- Issue:
- 5
- Pages:
- 886-899
- Publication date:
- 2019-02-20
- Acceptance date:
- 2018-10-28
- DOI:
- EISSN:
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1554-8635
- ISSN:
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1554-8627
- Pubs id:
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pubs:935298
- URN:
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uri:244b1ff6-de0f-4537-91df-a667a5c483d0
- UUID:
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uuid:244b1ff6-de0f-4537-91df-a667a5c483d0
- Local pid:
- pubs:935298
Terms of use
- Copyright holder:
- Wang et al.
- Copyright date:
- 2019
- Notes:
- © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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