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Journal article

Role of EphA4 and EphrinB3 in local neuronal circuits that control walking.

Abstract:

Local circuits in the spinal cord that generate locomotion are termed central pattern generators (CPGs). These provide coordinated bilateral control over the normal limb alternation that underlies walking. The molecules that organize the mammalian CPG are unknown. Isolated spinal cords from mice lacking either the EphA4 receptor or its ligand ephrinB3 have lost left-right limb alternation and instead exhibit synchrony. We identified EphA4-positive neurons as an excitatory component of the loc...

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Publication status:
Published

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Publisher copy:
10.1126/science.1079641

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Journal:
Science (New York, N.Y.)
Volume:
299
Issue:
5614
Pages:
1889-1892
Publication date:
2003-03-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:244635db-e2b2-447e-bf44-32a42216c9ff
Source identifiers:
114586
Local pid:
pubs:114586

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