Increased expression of CD44v6 and CD44v3 in ulcerative colitis but not colonic Crohn's disease.

Journal article

Immune mechanisms, possibly involving cell-surface molecules such as CD44, have been invoked to explain the pathogenesis of inflammatory bowel disease. We used monoclonal antibodies against epitopes encoded within the variable region of CD44 to investigate CD44 isoform expression in colon, small intestine, and liver in patients with various intestinal disorders and in controls. Biopsy samples from patients with ulcerative colitis showed significantly increased epithelial expression of CD44 is...

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Authors: Rosenberg, WM; Prince, C; Kaklamanis, L; Fox, S; Jackson, D

• Publication status: Published
• Journal: Lancet
• Volume: 345
• Issue: 8959
• Pages: 1205-1209
• Publication date: 1995-05-01
• DOI: 10.1016/s0140-6736(95)91991-0
• EISSN: 1474-547X
• ISSN: 0140-6736
• Language: English
• Keywords: Female; Receptors, Cell Surface; Receptors, Lymphocyte Homing; Gastrointestinal Diseases; Antibodies, Monoclonal; Humans; Antigens, CD44; Carrier Proteins; Epitopes; Colitis, Ulcerative; Crohn Disease; Middle Aged; Male