Defining the HLA class I-associated viral antigen repertoire from HIV-1-infected human cells.
Recognition and eradication of infected cells by cytotoxic T lymphocytes is a key defense mechanism against intracellular pathogens. High-throughput definition of HLA class I-associated immunopeptidomes by mass spectrometry is an increasingly important analytical tool to advance our understanding of the induction of T-cell responses against pathogens such as HIV-1. We utilized a liquid chromatography tandem mass spectrometry workflow including de novo-assisted database searching to define the...Expand abstract
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- Peer reviewed
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- Ternette et al
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- © 2015 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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