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Journal article

Modulation of Escherichia coli sister chromosome cohesion by topoisomerase IV.

Abstract:

A body of evidence supports the idea that newly replicated Escherichia coli chromosomes segregate progressively as replication progresses, with spatial separation of sister genetic loci occurring approximately 15 min after their replication. We show that the time of this cohesion can be modulated by topoisomerase IV (TopoIV) activity. Impairment of TopoIV prevents segregation of newly replicated sister loci and bulk chromosome segregation, whereas modest increases in TopoIV decrease the cohes...

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Publication status:
Published

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Publisher copy:
10.1101/gad.487508

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Genes and development More from this journal
Volume:
22
Issue:
17
Pages:
2426-2433
Publication date:
2008-09-01
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
Language:
English
Keywords:
Pubs id:
pubs:3947
UUID:
uuid:243e45aa-432a-41d3-a3f1-d24ef53175bb
Local pid:
pubs:3947
Source identifiers:
3947
Deposit date:
2012-12-19

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