Journal article icon

Journal article

Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis

Abstract:

Genome-wide association studies (GWAS) linking polymorphisms in ATG16L1 with susceptibility to inflammatory bowel disease (IBD) have prompted mucosal immunologists to investigate the functional roles of macroautophagy/autophagy in different cell types in the gut. Here we present a recent study that addressed 2 key questions: in which cell type is autophagy deficiency most detrimental during chronic colitis and what is the functional role of autophagy in those cells? We report that autophagy i...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0003-4439-725X
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More from this funder
Name:
Wellcome Trust
Grant:
102972
More from this funder
Name:
Medical Research Council
Grant:
MR/N02379X/1
Publisher:
Taylor and Francis
Journal:
Autophagy More from this journal
Volume:
14
Issue:
8
Pages:
1460-1461
Publication date:
2018-05-25
Acceptance date:
2018-02-28
DOI:
EISSN:
1554-8635
ISSN:
1554-8627
Pmid:
29799774
Language:
English
Keywords:
Pubs id:
pubs:854542
UUID:
uuid:243a02cd-5d55-441a-824b-101a40b8997d
Local pid:
pubs:854542
Source identifiers:
854542
Deposit date:
2018-06-07

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP