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A four‐compartment multiscale model of fluid and drug distribution in vascular tumours

Abstract:

The subtle relationship between vascular network structure and mass transport is vital to predict and improve the efficacy of anticancer treatments. Here, mathematical homogenisation is used to derive a new multiscale continuum model of blood and chemotherapy transport in the vasculature and interstitium of a vascular tumour. This framework enables information at a range of vascular hierarchies to be fed into an effective description on the length scale of the tumour. The model behaviour is e...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-2818-6228
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Role:
Author
ORCID:
0000-0003-3385-0696
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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
ORCID:
0000-0003-3347-6024
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Name:
Rosetrees Trust
Grant:
M601
Publisher:
Wiley
Journal:
International Journal for Numerical Methods in Biomedical Engineering More from this journal
Volume:
36
Issue:
3
Article number:
e3315
Publication date:
2020-02-07
Acceptance date:
2020-01-17
DOI:
EISSN:
2040-7947
ISSN:
2040-7939
Pmid:
32031302
Language:
English
Keywords:
Pubs id:
1087394
Local pid:
pubs:1087394
Deposit date:
2020-04-24

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