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Serum and mucosal antibody responses to pneumococcal protein antigens in children: relationships with carriage status

Abstract:
Streptococcus pneumoniae causes significant morbidity and mortality especially in children. Some pneumococcal protein antigens can protect mice against infection. Little information is available concerning the nature of naturally acquired protective immunity to pneumococci in humans induced by these antigens. This study investigates the relationships between systemic and local antibody production and carriage in children. Children undergoing adenoidectomy (n=112, ages 2-12 years) wer... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/eji.200535101

Authors


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Institution:
University of Bristol
Department:
Department of Clinical Sciences South Bristol,Institute of Child Health
Role:
Author
More by this author
Institution:
University of Bristol
Department:
Department of Clinical Sciences South Bristol,Institute of Child Health
Role:
Author
More by this author
Institution:
University of Bristol
Department:
Department of Clinical Sciences South Bristol,Institute of Child Health
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Paediatrics,Department of
Role:
Author
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Institution:
University of Glasgow
Department:
Division of Infection & Immunity
Role:
Author
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David Telling Charitable Trust More from this funder
Special Trustees of the United Bristol Healthcare Trust More from this funder
North Bristol NHS Trust Research Foundation More from this funder
Publisher:
Wiley Publisher's website
Journal:
European Journal of Immunology Journal website
Volume:
36
Issue:
1
Pages:
46-57
Publication date:
2006-01-05
DOI:
EISSN:
1521-4141
URN:
uuid:242d899b-193f-47e0-97f1-3da9b26af831
Local pid:
ora:4242

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