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Diffusive spatio-temporal noise in a first-passage time model for intracellular calcium release

Abstract:

The intracellular release of calcium from the endoplasmic reticulum is controlled by ion channels. The resulting calcium signals exhibit a rich spatio-temporal signature, which originates at least partly from microscopic fluctuations. While stochasticity in the gating transition of ion channels has been incorporated into many models, the distribution of calcium is usually described by deterministic reaction-diffusion equations. Here we test the validity of the latter modeling approach by usin...

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M. B. Flegg More by this author
Publication date:
2013
URN:
uuid:242b9e68-c346-4c0b-ac0f-a7cd79e6ddf1
Local pid:
oai:eprints.maths.ox.ac.uk:1782

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