- Abstract:
-
The phosphoprotein (P) is the main and essential cofactor of the RNA polymerase (L) of non-segmented, negative-strand RNA viruses. P positions the viral polymerase onto its nucleoprotein-RNA template and acts as a chaperone of the nucleoprotein (N), thereby preventing nonspecific encapsidation of cellular RNAs. The phosphoprotein of human metapneumovirus (HMPV) forms homotetramers composed of a stable oligomerization domain (Pcore) flanked by large intrinsically disordered regions (IDRs). Her...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 7.8mb)
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- Publisher copy:
- 10.1038/s41598-017-14448-z
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 7
- Issue:
- 1
- Pages:
- 14865
- Publication date:
- 2017-11-05
- Acceptance date:
- 2017-10-10
- DOI:
- EISSN:
-
2045-2322
- Pubs id:
-
pubs:744979
- URN:
-
uri:242a73ac-de72-460b-b899-bfe6113ed011
- UUID:
-
uuid:242a73ac-de72-460b-b899-bfe6113ed011
- Local pid:
- pubs:744979
- Language:
- English
- Keywords:
- Copyright holder:
- Grimes et al
- Copyright date:
- 2017
- Notes:
- © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Journal article
Structural dissection of human metapneumovirus phosphoprotein using small angle x-ray scattering.
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