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Structural dissection of human metapneumovirus phosphoprotein using small angle x-ray scattering.

Abstract:

The phosphoprotein (P) is the main and essential cofactor of the RNA polymerase (L) of non-segmented, negative-strand RNA viruses. P positions the viral polymerase onto its nucleoprotein-RNA template and acts as a chaperone of the nucleoprotein (N), thereby preventing nonspecific encapsidation of cellular RNAs. The phosphoprotein of human metapneumovirus (HMPV) forms homotetramers composed of a stable oligomerization domain (Pcore) flanked by large intrinsically disordered regions (IDRs). Her...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-017-14448-z

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Biology
Grison, CM More by this author
Granier, S More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Biology
Oxford college:
New College
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French National Research Agency More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Issue:
1
Pages:
14865
Publication date:
2017-11-05
Acceptance date:
2017-10-10
DOI:
EISSN:
2045-2322
Pubs id:
pubs:744979
URN:
uri:242a73ac-de72-460b-b899-bfe6113ed011
UUID:
uuid:242a73ac-de72-460b-b899-bfe6113ed011
Local pid:
pubs:744979
Language:
English
Keywords:

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