Journal article icon

Journal article

Synergistic effects of osteonectin and brain-derived neurotrophic factor on axotomized retinal ganglion cells neurite outgrowth via the mitogen-activated protein kinase-extracellular signal-regulated kinase 1/2 pathways.

Abstract:

Our previous study identified osteonectin (ON) in a screen of factors made by Schwann cells (SCs) which promoted peripheral and central neurons survival and neuritogenesis, however, the mechanisms of ON promoting effects are largely unknown. In the present study, we investigated the effects of ON-deficient SC-conditioned medium (SCCM) and molecular mechanisms of ON, in regulating retinal ganglion cells (RGCs) survival and neurite outgrowth. Neonatal rat RGCs and SCs were purified by immunopan...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Bampton, ET More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Neuroscience
Volume:
165
Issue:
2
Pages:
463-474
Publication date:
2010-01-05
DOI:
EISSN:
1873-7544
ISSN:
0306-4522
URN:
uuid:242932b0-0d2e-42eb-8186-52a34f2aa3af
Source identifiers:
95236
Local pid:
pubs:95236

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP