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Journal article

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.

Abstract:

Nitric oxide, generated by the nitric oxide synthase (NOS) enzymes, plays pivotal roles in cardiovascular homeostasis and in the pathogenesis of cardiovascular disease. The NOS cofactor, tetrahydrobiopterin (BH4), is an important regulator of NOS function, since BH4 is required to maintain enzymatic coupling of L-arginine oxidation, to produce NO. Loss or oxidation of BH4 to 7,8-dihydrobiopterin (BH2) is associated with NOS uncoupling, resulting in the production of superoxide rather than NO....

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Publication status:
Published

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Publisher copy:
10.1016/j.niox.2011.04.004

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Role:
Author
Journal:
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society
Volume:
25
Issue:
2
Pages:
81-88
Publication date:
2011-08-05
DOI:
EISSN:
1089-8611
ISSN:
1089-8603
URN:
uuid:242713a7-c95d-48e5-bb40-2bc0b18f9e1e
Source identifiers:
138839
Local pid:
pubs:138839

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