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Journal article

The prospects of an active vaccine against asthma targeting IL-5

Abstract:

Allergen-specific T helper type 2 (Th2) responses followed by eosinophilic inflammation of the lung are important causes of allergic asthma. Interleukin-5 (IL-5) is a master regulator of eosinophil differentiation as well as activation. Blocking IL-5 using monoclonal antibodies (mAbs) against IL-5 is a powerful way to improve asthmatic symptoms in patients with an eosinophilic component of the disease. We have previously shown that vaccination against IL-5 can abrogate eosinophilic inflammati...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fmicb.2018.02522

Authors


Bachmann, MF More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
CCMP
Fettelschoss-Gabriel, A More by this author
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Microbiology Journal website
Volume:
9
Issue:
OCT
Pages:
2522
Publication date:
2018-10-24
Acceptance date:
2018-10-03
DOI:
EISSN:
1664-302X
ISSN:
1664-302X
Pubs id:
pubs:938545
URN:
uri:24248bb2-2161-4596-9f07-f4c1ba76923e
UUID:
uuid:24248bb2-2161-4596-9f07-f4c1ba76923e
Local pid:
pubs:938545

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