- Abstract:
-
Allergen-specific T helper type 2 (Th2) responses followed by eosinophilic inflammation of the lung are important causes of allergic asthma. Interleukin-5 (IL-5) is a master regulator of eosinophil differentiation as well as activation. Blocking IL-5 using monoclonal antibodies (mAbs) against IL-5 is a powerful way to improve asthmatic symptoms in patients with an eosinophilic component of the disease. We have previously shown that vaccination against IL-5 can abrogate eosinophilic inflammati...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 233.6kb)
-
- Publisher copy:
- 10.3389/fmicb.2018.02522
-
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- Publisher:
- Frontiers Media Publisher's website
- Journal:
- Frontiers in Microbiology Journal website
- Volume:
- 9
- Issue:
- OCT
- Pages:
- 2522
- Publication date:
- 2018-10-24
- Acceptance date:
- 2018-10-03
- DOI:
- EISSN:
-
1664-302X
- ISSN:
-
1664-302X
- Pubs id:
-
pubs:938545
- URN:
-
uri:24248bb2-2161-4596-9f07-f4c1ba76923e
- UUID:
-
uuid:24248bb2-2161-4596-9f07-f4c1ba76923e
- Local pid:
- pubs:938545
- Language:
- English
- Keywords:
- Copyright holder:
- Bachmann et al
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Bachmann, El-Turabi, Fettelschoss-Gabriel and Vogel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Journal article
The prospects of an active vaccine against asthma targeting IL-5
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