A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis.

Journal article

OBJECTIVE: Interleukin-6 is a pro-inflammatory cytokine involved in the pathogenesis of osteoarthritis (OA). We investigated the role of two single nucleotide polymorphisms (SNPs) mapping to the promoter of the IL-6 gene on genetic susceptibility to hip and knee OA. METHODS: The -174G/C (rs1800795) and -597G/A (rs1800797) SNPs, implicated in the literature in risk of hip and hand OA, were genotyped in 2511 controls, 1101 hip OA cases and 1904 knee OA cases from four cohorts from the UK and Es...

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Authors: Valdes, A; Arden, N; Tamm, A; Kisand, K; Doherty, S

• Publication status: Published
• Journal: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
• Volume: 18
• Issue: 5
• Pages: 699-704
• Publication date: 2010-05-01
• DOI: 10.1016/j.joca.2009.12.012
• EISSN: 1522-9653
• ISSN: 1063-4584
• Language: English
• Keywords: Gene Frequency; Genotype; Cohort Studies; Humans; Risk Factors; Genetic Predisposition to Disease; Promoter Regions, Genetic; Osteoarthritis, Hip; Genetic Linkage; Polymorphism, Single Nucleotide; Interleukin-6; Osteoarthritis, Knee