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TGF- 2signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution

Abstract:

The thymus constitutes the primary lymphoid organ responsible for the generation of naive T cells. Its stromal compartment is largely composed of a scaffold of different subsets of epithelial cells that provide soluble and membrane-bound molecules essential for thymocyte maturation and selection. With senescence, a steady decline in the thymic output of T cells has been observed. Numeric and qualitative changes in the stromal compartment of the thymus resulting in re-duced thymopoietic capaci...

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Journal:
Blood
Volume:
112
Issue:
3
Pages:
626-634
Publication date:
2008-08-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:241e5f0f-6e3f-44c0-93c7-30e292dffe82
Source identifiers:
309060
Local pid:
pubs:309060
Language:
English

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