Ag-catalyzed stereoselective aminosulfonylation of alkynes
- A silver-catalyzed intermolecular aminosulfonylation of terminal alkynes with sodium sulfinates and TMSN3 is reported. This three component reaction proceeds through sequential hydroazidation of the terminal alkyne, and addition of a sulfonyl radical to the resultant vinyl azide. The method enables the stereoselective synthesis of a wide range of β-sulfonyl enamines without electron-withdrawing groups on the nitrogen atom, which are found to be suitable for a variety of further transformations.
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- © 2017 Ning, et al
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- ©The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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