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Journal article

Regulatory cells in transplantation.

Abstract:

Regulatory T cells can play an important role in both the induction and maintenance of tolerance to donor alloantigens in vivo. Regulatory activity specific for donor alloantingens is enriched amongst CD4+CD25+ T cells in some settings and can be induced by manipulating the immune system before transplantation. Donor alloantigen-specific CD4+CD25+ regulatory T cells can control aggressive CD4+ as well as CD8+ T cells thereby preventing rejection and can mediate linked unresponsiveness. In viv...

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
Journal:
Novartis Foundation symposium More from this journal
Volume:
252
Pages:
177-210
Publication date:
2003-01-01
EISSN:
1935-4657
ISSN:
1528-2511
Language:
English
Keywords:
Pubs id:
pubs:135951
UUID:
uuid:2416b66c-71a6-46e9-9594-00fd109df2a9
Local pid:
pubs:135951
Source identifiers:
135951
Deposit date:
2013-02-20

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