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Prevalence of anti-basal ganglia antibodies in adult obsessive-compulsive disorder: cross-sectional study.

Abstract:

BACKGROUND: Symptoms of obsessive-compulsive disorder (OCD) have been described in neuropsychiatric syndromes associated with streptococcal infections. It is proposed that antibodies raised against streptococcal proteins cross-react with neuronal proteins (antigens) in the brain, particularly in the basal ganglia, which is a brain region implicated in OCD pathogenesis. AIMS: To test the hypothesis that post-streptococcal autoimmunity, directed against neuronal antigens, may contribute to the...

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Publication status:
Published

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Publisher copy:
10.1192/bjp.bp.111.092007

Authors


Nicholson, TR More by this author
Ferdinando, S More by this author
Krishnaiah, RB More by this author
Anhoury, S More by this author
Lennox, BR More by this author
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Journal:
The British journal of psychiatry : the journal of mental science
Volume:
200
Issue:
5
Pages:
381-386
Publication date:
2012-05-05
DOI:
EISSN:
1472-1465
ISSN:
0007-1250
URN:
uuid:24162fa5-1459-45cc-8f5c-a5ac722fa47c
Source identifiers:
355963
Local pid:
pubs:355963

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