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The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain.

Abstract:

Recognition of antigen by cytotoxic T lymphocytes (CTL) is determined by interaction of both the T cell receptor and its CD8 coreceptor with peptide-major histocompatibility complex (pMHC) class I molecules. We examine the relative roles of these receptors in the activation of human CTL using mutations in MHC class I designed to diminish or abrogate the CD8/pMHC interaction. We use surface plasmon resonance to determine that point mutation of the alpha3 loop of HLA A2 abrogates the CD8/pMHC i...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m102498200

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Journal:
Journal of biological chemistry More from this journal
Volume:
276
Issue:
35
Pages:
32786-32792
Publication date:
2001-08-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258

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