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Profound biopterin oxidation and protein tyrosine nitration in tissues of ApoE-null mice on an atherogenic diet: contribution of inducible nitric oxide synthase.

Abstract:

Diminished nitric oxide (NO) bioactivity and enhanced peroxynitrite formation have been implicated as major contributors to atherosclerotic vascular dysfunctions. Hallmark reactions of peroxynitrite include the accumulation of 3-nitrotyrosine (3-NT) in proteins and oxidation of the NO synthase (NOS) cofactor, tetrahydrobiopterin (BH(4)). The present study sought to 1) quantify the extent to which 3-NT accumulates and BH(4) becomes oxidized in organs of apolipoprotein E-deficient (ApoE(-/-)) a...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.01144.2006

Authors


Upmacis, RK More by this author
Crabtree, MJ More by this author
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Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
293
Issue:
5
Pages:
H2878-H2887
Publication date:
2007-11-05
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
URN:
uuid:240c67e5-8070-4b8f-ac94-0c96b1b7b591
Source identifiers:
342140
Local pid:
pubs:342140

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