- Abstract:
-
Diminished nitric oxide (NO) bioactivity and enhanced peroxynitrite formation have been implicated as major contributors to atherosclerotic vascular dysfunctions. Hallmark reactions of peroxynitrite include the accumulation of 3-nitrotyrosine (3-NT) in proteins and oxidation of the NO synthase (NOS) cofactor, tetrahydrobiopterin (BH(4)). The present study sought to 1) quantify the extent to which 3-NT accumulates and BH(4) becomes oxidized in organs of apolipoprotein E-deficient (ApoE(-/-)) a...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1152/ajpheart.01144.2006
-
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- Journal:
- American journal of physiology. Heart and circulatory physiology
- Volume:
- 293
- Issue:
- 5
- Pages:
- H2878-H2887
- Publication date:
- 2007-11-05
- DOI:
- EISSN:
-
1522-1539
- ISSN:
-
0363-6135
- URN:
-
uuid:240c67e5-8070-4b8f-ac94-0c96b1b7b591
- Source identifiers:
-
342140
- Local pid:
- pubs:342140
- Copyright date:
- 2007
Journal article
Profound biopterin oxidation and protein tyrosine nitration in tissues of ApoE-null mice on an atherogenic diet: contribution of inducible nitric oxide synthase.
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