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CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

Abstract:

Neuroinflammation and microglial activation are significant processes in Alzheimer's disease pathology. Recent genome-wide association studies have highlighted multiple immune-related genes in association with Alzheimer's disease, and experimental data have demonstrated microglial proliferation as a significant component of the neuropathology. In this study, we tested the efficacy of the selective CSF1R inhibitor JNJ-40346527 (JNJ-527) in the P301S mouse tauopathy model. We first demonstrated...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/brain/awz241

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Structural Genomics Consortium
Department:
Unknown
Role:
Author
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Name:
Wellcome Trust
Grant:
104025/Z/14/Z
Publisher:
Oxford University Press
Journal:
Brain More from this journal
Volume:
142
Issue:
10
Pages:
3243-3264
Publication date:
2019-08-26
Acceptance date:
2019-06-14
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Pmid:
31504240
Language:
English
Pubs id:
pubs:1053471
UUID:
uuid:24088824-c365-4db8-9f04-9b84ab234e17
Local pid:
pubs:1053471
Source identifiers:
1053471
Deposit date:
2020-01-13

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