Journal article
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
- Abstract:
-
Neuroinflammation and microglial activation are significant processes in Alzheimer's disease pathology. Recent genome-wide association studies have highlighted multiple immune-related genes in association with Alzheimer's disease, and experimental data have demonstrated microglial proliferation as a significant component of the neuropathology. In this study, we tested the efficacy of the selective CSF1R inhibitor JNJ-40346527 (JNJ-527) in the P301S mouse tauopathy model. We first demonstrated...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Brain Journal website
- Volume:
- 142
- Issue:
- 10
- Pages:
- 3243-3264
- Publication date:
- 2019-08-26
- Acceptance date:
- 2019-06-14
- DOI:
- EISSN:
-
1460-2156
- ISSN:
-
0006-8950
- Pmid:
-
31504240
Item Description
- Language:
- English
- Pubs id:
-
pubs:1053471
- UUID:
-
uuid:24088824-c365-4db8-9f04-9b84ab234e17
- Local pid:
- pubs:1053471
- Source identifiers:
-
1053471
- Deposit date:
- 2020-01-13
Terms of use
- Copyright holder:
- Mancuso et al
- Copyright date:
- 2019
- Notes:
- © The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record