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Benefit of dexamethasone compared with prednisolone for childhood acute lymphoblastic leukaemia: results of the UK Medical Research Council ALL97 randomized trial.

Abstract:

Corticosteroids are an essential component of treatment for acute lymphoblastic leukaemia (ALL). Prednisolone is the most commonly used steroid, particularly in the maintenance phase of therapy. There is increasing evidence that, even in equipotent dosage for glucocorticoid effect, dexamethasone has enhanced lymphoblast cytotoxicity and penetration of the central nervous system (CNS) compared with prednisolone. Substitution of dexamethasone for prednisolone in the treatment of ALL might, ther...

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Publication status:
Published

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Journal:
British journal of haematology More from this journal
Volume:
129
Issue:
6
Pages:
734-745
Publication date:
2005-06-01
DOI:
EISSN:
1365-2141
ISSN:
0007-1048

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