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Detection of antibody-dependent complement-mediated inactivation of both autologous and heterologous virus in primary human immunodeficiency virus type 1 infection.

Abstract:

Specific CD8 T-cell responses to human immunodeficiency virus type 1 (HIV-1) are induced in primary infection and make an important contribution to the control of early viral replication. The importance of neutralizing antibodies in containing primary viremia is questioned because they usually arise much later. Nevertheless antienvelope antibodies develop simultaneously with, or even before, peak viremia. We determined whether such antibodies might control viremia by complement-mediated inact...

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Journal:
Journal of virology
Volume:
79
Issue:
5
Pages:
2823-2830
Publication date:
2005-03-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Source identifiers:
32996
Language:
English
Keywords:
Pubs id:
pubs:32996
UUID:
uuid:23f7aeff-0b66-4fed-8fc1-388ace2d83a2
Local pid:
pubs:32996
Deposit date:
2012-12-20

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