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Journal article

A functional and kinetic comparison of antiviral effector and memory cytotoxic T lymphocyte populations in vivo and in vitro.

Abstract:

To analyze the critical parameters for effective antiviral cytotoxic T lymphocyte (CTL) activity in vivo, control of lymphocytic choriomeningitis virus (LCMV) infection in the spleen was studied after adoptive transfer of different spleen cell populations into preinfected recipients. The quantitative, qualitative and kinetic requirements for virus control were defined and related to in vitro assays to compare the antiviral protective function of CTL from naive, acutely infected and memory mic...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830271240

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
European journal of immunology More from this journal
Volume:
27
Issue:
12
Pages:
3404-3413
Publication date:
1997-12-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Language:
English
Keywords:
Pubs id:
pubs:4631
UUID:
uuid:23ef33f6-6aa9-48b9-bb04-aeb7500ddc87
Local pid:
pubs:4631
Source identifiers:
4631
Deposit date:
2012-12-19

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