A functional and kinetic comparison of antiviral effector and memory cytotoxic T lymphocyte populations in vivo and in vitro.

Journal article

To analyze the critical parameters for effective antiviral cytotoxic T lymphocyte (CTL) activity in vivo, control of lymphocytic choriomeningitis virus (LCMV) infection in the spleen was studied after adoptive transfer of different spleen cell populations into preinfected recipients. The quantitative, qualitative and kinetic requirements for virus control were defined and related to in vitro assays to compare the antiviral protective function of CTL from naive, acutely infected and memory mic...

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Authors: Ehl, S; Klenerman, P; Aichele, P; Hengartner, H; Zinkernagel, R

• Publication status: Published
• Journal: European journal of immunology
• Volume: 27
• Issue: 12
• Pages: 3404-3413
• Publication date: 1997-12-01
• DOI: 10.1002/eji.1830271240
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Lymphocyte Activation; Adoptive Transfer; Mice, Inbred C57BL; T-Lymphocytes, Cytotoxic; Cells, Cultured; Cytotoxicity, Immunologic; Lymphocytic choriomeningitis virus; Animals; Immunologic Memory; Lymphocytic Choriomeningitis; Mice