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Eliciting cytotoxic T lymphocytes against acute myeloid leukemia-derived antigens: evaluation of dendritic cell-leukemia cell hybrids and other antigen-loading strategies for dendritic cell-based vaccination.

Abstract:

Dendritic cells (DC) have been successfully used in clinical pilot studies to induce tumor-specific immunity as well as clinical response in selected patients. However, DC-based immunotherapy remains a challenge and several parameters need to be examined in order to optimize the induction of anti-tumor immune responses. This study focuses on DC vaccination for leukemia and evaluates the in vitro efficacy of three different strategies for generating antigen-loaded DC-based vaccines for the ind...

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Publication status:
Published

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Publisher copy:
10.1007/s00262-002-0284-4

Authors


Journal:
Cancer immunology, immunotherapy : CII
Volume:
51
Issue:
6
Pages:
299-310
Publication date:
2002-08-05
DOI:
EISSN:
1432-0851
ISSN:
0340-7004
URN:
uuid:23ea59da-e8d6-4e9c-a3df-989eecb4793e
Source identifiers:
466389
Local pid:
pubs:466389

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