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Dynamic haematopoietic cell contribution to the developing and adult epicardium

Abstract:

The epicardium is a cellular source with the potential to reconstitute lost cardiovascular tissue following myocardial infarction. Here we show that the adult epicardium contains a population of CD45+ haematopoietic cells (HCs), which are located proximal to coronary vessels and encased by extracellular matrix (ECM). This complex tertiary structure is established during the regenerative window between post-natal days 1 and 7. We show that these HCs proliferate within the first 24 h and are re...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms5054

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Publisher:
Springer Nature
Journal:
Nature Communications More from this journal
Volume:
5
Article number:
4054
Publication date:
2014-06-06
Acceptance date:
2014-05-07
DOI:
EISSN:
2041-1723
Language:
English
Keywords:
UUID:
uuid:23e81163-a2d1-46d0-8008-54c996c1d357
Local pid:
pubs:469374
Source identifiers:
469374
Deposit date:
2015-01-16

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