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Altered expression of TGF alpha and TGF beta 1 in the mucosa of the functioning pelvic ileal pouch.

Abstract:

The mucosa of the functioning pelvic ileal pouch undergoes loss of villous height and an increase in crypt cell proliferation as an adaptive response to its new luminal environment. These changes can occur in the absence of inflammation and could be mediated by growth factors such as transforming growth factors alpha and beta 1 (TGF alpha and TGF beta 1). Expression of TGF alpha and TGF beta 1 messenger RNA (mRNA) and protein was determined by in situ hybridization and immunohistochemistry in...

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Publication status:
Published

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Authors


Campbell, AP More by this author
Smithson, J More by this author
Kettlewell, MG More by this author
Mortensen, N More by this author
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Journal:
The Journal of pathology
Volume:
180
Issue:
4
Pages:
407-414
Publication date:
1996-12-05
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
URN:
uuid:23d9f89c-283b-400a-a18d-694b54e82b01
Source identifiers:
135455
Local pid:
pubs:135455

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