Journal article icon

Journal article

Imaging DNA damage response (DDR) during oncogenesis

Abstract:

Introduction: DNA damage repair (DDR) signalling is upregulated during tumorigenesis and acts as a p53-mediated block on proliferation. Expression of the DNA double strand break (DSB) repair protein, γH2AX, is induced by the activated kinases pATM or pATR during oncogenesis. Previously, we showed that γH2AX presents an abundant epitope for non-invasive in vivo imaging of DSBs. We used 111In-labelled anti-γH2AX antibodies, conjugated to the cell penetrating peptide, TAT, to non-invasively i...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Publisher:
American Association for Cancer Research
Journal:
Cancer Research More from this journal
Volume:
73
Issue:
8
Article number:
1062
Publication date:
2013-01-01
DOI:
ISSN:
0008-5472
Pubs id:
pubs:458425
UUID:
uuid:23d8608d-98d5-4b71-9fd1-4e76fd8736d2
Local pid:
pubs:458425
Source identifiers:
458425
Deposit date:
2015-11-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP