Journal article
Imaging DNA damage response (DDR) during oncogenesis
- Abstract:
-
Introduction: DNA damage repair (DDR) signalling is upregulated during tumorigenesis and acts as a p53-mediated block on proliferation. Expression of the DNA double strand break (DSB) repair protein, γH2AX, is induced by the activated kinases pATM or pATR during oncogenesis. Previously, we showed that γH2AX presents an abundant epitope for non-invasive in vivo imaging of DSBs. We used 111In-labelled anti-γH2AX antibodies, conjugated to the cell penetrating peptide, TAT, to non-invasively i...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- American Association for Cancer Research Publisher's website
- Journal:
- Cancer Research Journal website
- Volume:
- 73
- Issue:
- 8
- Article number:
- 1062
- Publication date:
- 2013-01-01
- DOI:
- ISSN:
-
0008-5472
Item Description
- Pubs id:
-
pubs:458425
- UUID:
-
uuid:23d8608d-98d5-4b71-9fd1-4e76fd8736d2
- Local pid:
- pubs:458425
- Source identifiers:
-
458425
- Deposit date:
- 2015-11-19
Terms of use
- Copyright holder:
- American Association for Cancer Research
- Copyright date:
- 2013
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