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Journal article

Increased detection of proliferating, polyfunctional, HIV-1-specific T cells in DNA-modified vaccinia virus Ankara-vaccinated human volunteers by cultured IFN-gamma ELISPOT assay.

Abstract:

Induction of a long-term immunological memory, which can expand and defend the host upon pathogen encounter, is the "holy grail" of vaccinology. Here, using a sensitive cultured IFN-gamma ELISPOT assay, we show that 50% (15 out of 30) of healthy, HIV-1/2-uninfected volunteers who received pTHr.HIVA DNA prime-modified vaccinia virus Ankara. HIVA boost vaccine regimen 1 to 3 1/2 years ago had detectable HIV-1-specific T-cell responses. These T cells, predominantly of the CD4(+) subtype, could p...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200839167

Authors


Winstone, N More by this author
Guimarães-Walker, A More by this author
Roberts, J More by this author
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Journal:
European journal of immunology
Volume:
39
Issue:
4
Pages:
975-985
Publication date:
2009-04-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:23d586ba-0ef4-45d9-8e8a-530057d08f44
Source identifiers:
34635
Local pid:
pubs:34635

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