Journal article
Increased detection of proliferating, polyfunctional, HIV-1-specific T cells in DNA-modified vaccinia virus Ankara-vaccinated human volunteers by cultured IFN-gamma ELISPOT assay.
- Abstract:
-
Induction of a long-term immunological memory, which can expand and defend the host upon pathogen encounter, is the "holy grail" of vaccinology. Here, using a sensitive cultured IFN-gamma ELISPOT assay, we show that 50% (15 out of 30) of healthy, HIV-1/2-uninfected volunteers who received pTHr.HIVA DNA prime-modified vaccinia virus Ankara. HIVA boost vaccine regimen 1 to 3 1/2 years ago had detectable HIV-1-specific T-cell responses. These T cells, predominantly of the CD4(+) subtype, could p...
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- Publication status:
- Published
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- Publisher copy:
- 10.1002/eji.200839167
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Authors
Bibliographic Details
- Journal:
- European journal of immunology
- Volume:
- 39
- Issue:
- 4
- Pages:
- 975-985
- Publication date:
- 2009-04-01
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- Source identifiers:
-
34635
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:34635
- UUID:
-
uuid:23d586ba-0ef4-45d9-8e8a-530057d08f44
- Local pid:
- pubs:34635
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2009
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