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Finer linkage mapping of primary hip osteoarthritis susceptibility on chromosome 11q in a cohort of affected female sibling pairs.

Abstract:

OBJECTIVE: To finer linkage-map a primary osteoarthritis (OA) susceptibility locus as a prerequisite to linkage disequilibrium/association analysis. METHODS: A 50-cM interval of chromosome 11q that we had previously identified as harboring susceptibility to hip OA in a female sibling-pair cohort was subjected to finer linkage mapping. Thirty-five microsatellite markers with a mean marker interval of 1.4 cM were genotyped in 146 families containing female sibling pairs who were concordant for...

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Publication status:
Published

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Publisher copy:
10.1002/art.10412

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Journal:
Arthritis and rheumatism
Volume:
46
Issue:
7
Pages:
1780-1783
Publication date:
2002-07-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:23d4c93e-907f-4328-a81b-8b2c61ba9642
Source identifiers:
107292
Local pid:
pubs:107292

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