Journal article icon

Journal article

Curvature- and fluid-stress-driven tissue growth in a tissue-engineering scaffold pore

Abstract:

Cell proliferation within a fluid-filled porous tissue-engineering scaffold depends on a sensitive choice of pore geometry and flow rates: regions of high curvature encourage cell proliferation, while a critical flow rate is required to promote growth for certain cell types. When the flow rate is too slow, the nutrient supply is limited; when it is too fast, cells may be damaged by the high fluid shear stress. As a result, determining appropriate tissue-engineering-construct geometries and op...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

Actions


Access Document


Files:
Publisher copy:
10.1007/s10237-018-1103-y

Authors


Cummings, LJ More by this author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
ORCID:
0000-0001-6882-7977
Publisher:
Springer Publisher's website
Journal:
Biomechanics and Modeling in Mechanobiology Journal website
Volume:
18
Issue:
3
Pages:
589–605
Publication date:
2018-12-12
Acceptance date:
2018-11-21
DOI:
EISSN:
1617-7940
ISSN:
1617-7959
Pubs id:
pubs:945833
URN:
uri:23d2028b-d857-4b8c-9cc8-48d98a59267c
UUID:
uuid:23d2028b-d857-4b8c-9cc8-48d98a59267c
Local pid:
pubs:945833

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP