Journal article icon

Journal article

Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides.

Abstract:
Novel technological advances have improved our understanding of how cyclic nucleotides are able to convey signals faithfully between cellular compartments. Phosphodiesterases play a crucial role in shaping these signals in health and disease. The concept of compartmentalization is guiding the search for therapies that have the potential to offer greater efficacy and tolerability compared with current treatments.

Actions


Access Document


Publisher copy:
10.1152/physiol.00040.2013

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
Publisher:
American Physiological Society
Journal:
Physiology (Bethesda, Md.)
Volume:
29
Issue:
2
Pages:
141-149
Publication date:
2014-03-05
DOI:
EISSN:
1548-9221
ISSN:
1548-9213
URN:
uuid:23cd614b-970e-48d3-a35e-3342a1ee66a7
Source identifiers:
451201
Local pid:
pubs:451201

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP