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Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides.

Abstract:
Novel technological advances have improved our understanding of how cyclic nucleotides are able to convey signals faithfully between cellular compartments. Phosphodiesterases play a crucial role in shaping these signals in health and disease. The concept of compartmentalization is guiding the search for therapies that have the potential to offer greater efficacy and tolerability compared with current treatments.

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Publisher copy:
10.1152/physiol.00040.2013

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Publisher:
American Physiological Society
Journal:
Physiology (Bethesda, Md.)
Volume:
29
Issue:
2
Pages:
141-149
Publication date:
2014-03-01
DOI:
EISSN:
1548-9221
ISSN:
1548-9213
Source identifiers:
451201
Language:
English
Keywords:
Pubs id:
pubs:451201
UUID:
uuid:23cd614b-970e-48d3-a35e-3342a1ee66a7
Local pid:
pubs:451201
Deposit date:
2014-05-13

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