Bradykinin receptor gene variant and human physical performance.

Journal article

Accumulating evidence suggests that athletic performance is strongly influenced by genetic variation. One such locus of influence is the gene for angiotensin-I converting enzyme (ACE), which exhibits a common variant [ACE insertion (I)/deletion (D)]. ACE can drive formation of vasoconstrictor ANG II but preferentially degrades vasodilator bradykinin. The ACE I allele is associated with higher kinin activity. A common gene variant in the kinin beta(2) receptor (B(2)R) exists: the -9 as opposed...

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Authors: Williams, A; Dhamrait, S; Wootton, P; Day, S; Hawe, E

• Publication status: Published
• Journal: Journal of applied physiology (Bethesda, Md. : 1985)
• Volume: 96
• Issue: 3
• Pages: 938-942
• Publication date: 2004-03-01
• DOI: 10.1152/japplphysiol.00865.2003
• EISSN: 1522-1601
• ISSN: 8750-7587
• Language: English
• Keywords: Analysis of Variance; Genetic Variation; Sports; Adult; Haplotypes; Exercise Test; Peptidyl-Dipeptidase A; Male; Receptors, Bradykinin; Chi-Square Distribution; Adolescent; Running; Genotype; Female; Humans