- Abstract:
-
DNA microarrays and specific reverse-transcription polymerase chain reaction assays were used to reveal transcriptional patterns in the blood of children presenting with dengue shock syndrome (DSS) and well-matched patients with uncomplicated dengue. The transcriptome of patients with acute uncomplicated dengue was characterized by a metabolically demanding "host-defense" profile; transcripts related to oxidative metabolism, interferon signaling, protein ubiquination, apoptosis, and cytokines...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1086/596507
-
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- Journal:
- The Journal of infectious diseases
- Volume:
- 199
- Issue:
- 4
- Pages:
- 537-546
- Publication date:
- 2009-02-05
- DOI:
- EISSN:
-
1537-6613
- ISSN:
-
0022-1899
- URN:
-
uuid:23cc1e45-dbf2-4665-a61f-db4695a80fcc
- Source identifiers:
-
34548
- Local pid:
- pubs:34548
- Language:
- English
- Keywords:
- Copyright date:
- 2009
Journal article
Patterns of gene transcript abundance in the blood of children with severe or uncomplicated dengue highlight differences in disease evolution and host response to dengue virus infection.
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