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Patterns of gene transcript abundance in the blood of children with severe or uncomplicated dengue highlight differences in disease evolution and host response to dengue virus infection.

Abstract:

DNA microarrays and specific reverse-transcription polymerase chain reaction assays were used to reveal transcriptional patterns in the blood of children presenting with dengue shock syndrome (DSS) and well-matched patients with uncomplicated dengue. The transcriptome of patients with acute uncomplicated dengue was characterized by a metabolically demanding "host-defense" profile; transcripts related to oxidative metabolism, interferon signaling, protein ubiquination, apoptosis, and cytokines...

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Publication status:
Published

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Publisher copy:
10.1086/596507

Authors


Hibberd, ML More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Van Ngoc, T More by this author
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Journal:
The Journal of infectious diseases
Volume:
199
Issue:
4
Pages:
537-546
Publication date:
2009-02-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:23cc1e45-dbf2-4665-a61f-db4695a80fcc
Source identifiers:
34548
Local pid:
pubs:34548

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