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Tightrope act: Autophagy in stem cell renewal, differentiation, proliferation, and aging

Abstract:

Autophagy is a constitutive lysosomal catabolic pathway that degrades damaged organelles and protein aggregates. Stem cells are characterized by self-renewal, pluripotency, and quiescence; their long life span, limited capacity to dilute cellular waste and spent organelles due to quiescence, along with their requirement for remodeling in order to differentiate, all suggest that they require autophagy more than other cell types. Here, we review the current literature on the role of autophagy i...

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Publisher copy:
10.1007/s00018-012-1032-3

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Cellular and Molecular Life Sciences
Volume:
70
Issue:
1
Pages:
89-103
Publication date:
2013-01-01
DOI:
EISSN:
1420-9071
ISSN:
1420-682X
Source identifiers:
379423
Pubs id:
pubs:379423
UUID:
uuid:23bdda95-9a32-4930-baa9-c0f03056a6af
Local pid:
pubs:379423
Deposit date:
2013-11-17

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