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Signal inhibitory receptor on leukocytes-1 is a novel functional inhibitory immune receptor expressed on human phagocytes.

Abstract:

Myeloid cells play a crucial role in controlling infection. Activation of these cells needs to be tightly regulated, because their potent effector functions can damage host tissue. Inhibitory receptors expressed by immune cells play an important role in restricting immune cell activation. In this study, we have characterized a hitherto unidentified ITIM-bearing receptor that is highly expressed on human neutrophils and monocytes: signal inhibitory receptor on leukocytes-1 (SIRL-1). The chromo...

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Publisher copy:
10.4049/jimmunol.0902039

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Journal of Immunology More from this journal
Volume:
184
Issue:
9
Pages:
4741-4748
Publication date:
2010-05-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Language:
English
Keywords:
Pubs id:
pubs:299848
UUID:
uuid:23bdd0a3-4e0a-464e-8af5-5b7c23100cc4
Local pid:
pubs:299848
Source identifiers:
299848
Deposit date:
2012-12-19

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