Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules.

Journal article

Centrosomes are the dominant sites of microtubule (MT) assembly during mitosis in animal cells, but it is unclear how this is achieved. Transforming acidic coiled coil (TACC) proteins stabilize MTs during mitosis by recruiting Minispindles (Msps)/XMAP215 proteins to centrosomes. TACC proteins can be phosphorylated in vitro by Aurora A kinases, but the significance of this remains unclear. We show that Drosophila melanogaster TACC (D-TACC) is phosphorylated on Ser863 exclusively at centrosomes...

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Authors: Barros, T; Kinoshita, K; Hyman, A; Raff, J

• Publication status: Published
• Journal: Journal of cell biology
• Volume: 170
• Issue: 7
• Pages: 1039-1046
• Publication date: 2005-09-01
• DOI: 10.1083/jcb.200504097
• EISSN: 1540-8140
• ISSN: 0021-9525
• Language: English
• Keywords: Serine; Drosophila Proteins; Protein-Serine-Threonine Kinases; Microtubule-Associated Proteins; Centrosome; Protein Kinases; Macromolecular Substances; Microtubules; Mutation; Animals; Phosphorylation; Mitosis; Cell Cycle Proteins; Xenopus Proteins