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Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules.

Abstract:

Centrosomes are the dominant sites of microtubule (MT) assembly during mitosis in animal cells, but it is unclear how this is achieved. Transforming acidic coiled coil (TACC) proteins stabilize MTs during mitosis by recruiting Minispindles (Msps)/XMAP215 proteins to centrosomes. TACC proteins can be phosphorylated in vitro by Aurora A kinases, but the significance of this remains unclear. We show that Drosophila melanogaster TACC (D-TACC) is phosphorylated on Ser863 exclusively at centrosomes...

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Publication status:
Published

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Publisher copy:
10.1083/jcb.200504097
Journal:
Journal of cell biology More from this journal
Volume:
170
Issue:
7
Pages:
1039-1046
Publication date:
2005-09-01
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
Language:
English
Keywords:
Pubs id:
pubs:223384
UUID:
uuid:23b90bfd-8cfc-447d-a158-3ae13e6e3387
Local pid:
pubs:223384
Source identifiers:
223384
Deposit date:
2012-12-19

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