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The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner

Abstract:

Background p68 (Ddx5) and p72 (Ddx17) are highly related members of the DEAD box family and are established RNA helicases. They have been implicated in growth regulation and have been shown to be involved in both pre-mRNA and pre-rRNA processing. More recently, however, these proteins have been reported to act as transcriptional co-activators for estrogen-receptor alpha (ERa). Furthermore these proteins were shown to interact with co-activators p300/CBP and the RNA polymerase II holoenzyme. T...

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Files:
  • (pdf, 893.8KB)
Journal:
BMC Molecular Biology
Publication date:
2004-01-01
Local pid:
ora:728

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