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Analysis of antibodies to newly described Plasmodium falciparum merozoite antigens supports MSPDBL2 as a predicted target of naturally acquired immunity.

Abstract:

Prospective studies continue to identify malaria parasite genes with particular patterns of polymorphism which indicate they may be under immune selection, and the encoded proteins require investigation. Sixteen new recombinant protein reagents were designed to characterize three such polymorphic proteins expressed in Plasmodium falciparum schizonts and merozoites: MSPDBL1 (also termed MSP3.4) and MSPDBL2 (MSP3.8), which possess Duffy binding-like (DBL) domains, and SURFIN4.2, encoded by a me...

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Publication status:
Published

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Publisher copy:
10.1128/iai.00301-13

Authors


Tetteh, KK More by this author
Salanti, A More by this author
Drought, L More by this author
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Journal:
Infection and immunity
Volume:
81
Issue:
10
Pages:
3835-3842
Publication date:
2013-10-05
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
URN:
uuid:23b58d7b-aee4-49fa-b986-002a819c91de
Source identifiers:
432592
Local pid:
pubs:432592

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